September 17


Epigenetics, Methylation Mental Health & Preconception Planning w/ Bill Walsh, PhD

By heheals

September 17, 2020

Bill Walsh, PhD discusses new insights about methylation, epigenetics and preconception planning.

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William J. Walsh:

Nutrient Power Book:

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04:26 During gestation, methylation attaches to parts of our DNA to determine and regulate what our genes do.
05:33 Each part of your body requires different ingredients/chemicals, yet your DNA is identical.
06:44 Methylation and methylation cycles determine what chemicals are being produced by your DNA. Epigenetics dictates the rate of production.
08:24 Seventy percent of Americans have normal methylation. Twenty-two percent are under-methylated and 8 percent are over-methylated.
08:55 If you are over-methylated, too many of your genes have a methylation bookmark. It enhances gene expression.
09:11 If you are under-methylated, you will not have as much methylation for gene expression.
10:50 Dr. Walsh found that over 95% of autistic children/people are under-methylated.
13:19 If you have homozygous MTHFR 677T, methylfolate is helpful for 90% of us with the mutations.
15:03 Methylation status can be reflected in the SAM-e/SAH ratio.
17:26 Test results of the SAM-e/SAH ratio, should be ignored if the SAH level is below 40%.
21:00 Histamine is metabolized/destroyed by methylation.
23:29 More than half of us with schizophrenia and 60% of us with panic disorders, are part of the 8 percent of our population who are over-methylated.
24:46 The median/normal homocysteine in the US is 12. Between 6 and 9 is a healthy range.
28:57 More people who have significant brain/mental problems are under-methylated, compared to 20 years ago.
30:07 Test genetics before becoming pregnant. Most birth defects, including autism, happen in the first 20 days after conception.
31:44 Having too much or too few important epigenetic factors, can do harm.
32:36 At least 7 most common nutrients imbalanced in mental illness have been identified.
38:30 Genetic mutations take place over hundreds or thousands of years.
40:06 We each have about 100,000 mutations.
41:28 We have the ability to change gene regulation with nutrients and with drugs.
42:40 Psychiatric meds will always have side effects and they will never normalize the brain.
49:39 Almost all cancers are epigenetic, as is most heart disease.
50:35 Writing, reading, deletion and making a protein are the major factors in epigenetics.
51:05 Most cancers involve the loss of a cancer protection gene. It varies from cell line to cell line. Cancer genes can be fixed/made normal, but the side effect profile is profound and the effects extensive.
52:00 Transcription factors sense a part of your DNA that can make a protein and they bring all of the pieces so the protein can be manufactured.
52:40 Bromodomain and chromodomain therapies can be used to change specific genes, gene expression, in a particular tissue.
53:07 MicroRNA therapies are in phase 1, 2 and 3 testing.
57:51 One mechanism explains the mysteries of bi-polar disorder and will be disclosed shortly.
01:00:19 Omega 3 fatty acids are more effective in helping bi-polar people than the drugs.
01:00:49 In the brain, 4 fatty acids dominate. They are DHA, EPA (omega-3), DGLA and arachidonic acid (omega-6).
01:03:11 Under-methylated people thrive on a protein based diet. People who are over-methylated thrive on a vegetarian diet.
01:05:47 Glial cells deliver nourishment to your 80 billion brain cells every day.
01:06:48 Glial cells are involved in brain scaffolding and plasticity. They sense when a neuron fires and moves the neurons closer together during learning.
01:09:26 Ageing is the deterioration of our DNA.
01:10:04 Dr. Walsh’s elevator pitch is for the government to stop killing off critical NIH research.
01:13:15 Schizophrenia is a name given to several completely different diseases. Depression can be one of 5 different disorders.
01:13:14 The number one reason that people decline mentally is from a zinc deficiency.



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  1. In my 30s and have had depression, among other health issues come up. Doctors can't make sense of it. I have my 23andme raw data, Prometheus, found my fitness report from Rhonda Patrick, Ben Lynch Dirty Genes book, and William Walsh's Nutrient Power and I still can't understand how to apply the knowledge to myself. If anyone is willing to help me understand a bit on how to apply the information I would be forever grateful. Also another great video Mike.

  2. IT'S the Story of

    Harry "EPIC" GENETICS and the balance of Chemistry

    "Harry! nobody had a clue…

    but that's not the whole story..

    2 of the world class myth-e-lation scientists

    …"they" found it was true 95% of autistic children do have undermethylation…

    but that's not the whole story..

    that started this whole business..

    but that's not the whole story..

    genetic testing, a wonderful thing in human health ..

    but that's not the whole story and you need to listen Harry..

    why we know what is best,

    now be impressed, be impressed

    by our vast knowledge about folate and it's effect on gene expression..

    but even that's not the whole story..

    it's about chemical imbalances we continue to find for you, a wonderful thing in human health ..

    and as you might have guessed, that's not the whole story..

    as we know from the people who do well on SSRI Medication,

    depression is just a lack of Serotonin..

    but that's not the whole story..

    it's that you get the Importance to believe this..

    !you need to balance the methylation cycle with the epigenetic effect!

    now that you know that Harry, balance all the imbalances with the medicinal magic given to you, before it vanishes..

    a wonderful story in human health.. isn't it?

  3. Hello I have followed Bill Walsh work for many years. He makes this information difficult to understand under and over methylation. You are very good at interpreting. Please add clarity and link any videos that you have done thanks.

  4. The total blind spot you and guest have regarding aluminum adjuvants in vaccines (ie 250mcg Al in HepB at birth) blows my mind. Do you remember your guest Dr. Paul Thomas?! Geez

  5. He started on it, but didn't specify. What testing should be done for a couple planning on having a child in the next year or two? At home testing available? I'm aware diet plays a huge role (we exercise and eat primal based), but asking what should be tested before a change is made. Thank you!

  6. I thought it was widely agreed-upon that the importance of dietary antioxidants was overplayed. I listened to Dr. David Sinclair I’m pretty sure I heard him say that dietary or supplemental antioxidants don’t do much. Correct me if I’m wrong.

  7. Though I appreciate this discussion, I found the information about SSRI/SNRI anti-depressants kind of frustrating. My opinion is that some depression is caused by many more factors than just a chemical imbalance in the brain. Personally in the last 12 months I have tried at least 6 different psychiatric drugs, the antidepressants came with a shit storm of side effects from gastrointestinal, panic attacks and debilitating depersonalisation/derealisation. I know they have helped many people, but if I could have had a blood test prior to being prescribed these medications that would have shown me they were incompatible with my genetics, I would have done it and saved myself a 10 month walk through mental health hell. The genetic compatibilty testing for medications need to be included in mainstream health care. Just my two cents worth on that issue. Love your work Mike 👍

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