September 18

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Genetics, epigenetics and disease

By heheals

September 18, 2020




Royal Society GlaxoSmithKline Prize Lecture given by Professor Adrian Bird CBE FMedSci FRS on Tuesday 22 January 2013.

Adrian Bird CBE FMedSci FRS is the Buchanan Chair of Genetics at the University of Edinburgh.

The human genome sequence has been available for more than a decade, but its significance is still not fully understood. While most human genes have been identified, there is much to learn about the DNA signals that control them. This lecture described an unusually short DNA sequence, just two base pairs long, CG, which occurs in several chemically different forms. Defects in signalling by CG are implicated in disease. For example, the autism spectrum disorder Rett syndrome is caused by loss of a protein that reads methylated CG and affects the activity of genes.

The Royal Society GlaxoSmithKline Prize Lecture is awarded for original contributions to medical and veterinary sciences published within ten years from the date of the award.

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  1. COMERCIALLY ENGAGED ?????? IS THERE NOT ENOUGH MAN-PRODUCED DAMAGE ON OUR PLANET BLINDLY "DEVELOPED" IN HUGE PROPORTIONS… AND EVEN BEFORE ALL THAT IS STILL BARELY UNDERSTOOD ??? MUST LEARN HOW INSTANT TRANSFORMATIONS  INSTANTLY CHANGE EVERYTHING, WITHIN OUR OWN BODIES AND  MINDS. STUDY  even when you think you “see” and “recognize” genes,  viruses and bacteria by observing them and giving them labels YOU, as observer, YOU must be aware that every time you look at more or less but unavoidably different extremely superficial mental scenarios  …    BE AWARE: WHAT YOU LEARN IS ABOUT SHOWING HOW OUR HUMAN POOR PERCEPTIONS digest our invisible to us instant interactions with our own environments,  and how our minds are depicting "SPECTACLES" OF YOUR “SCIENTIFIC” IMAGINATION.  What are our own minds after all???  Can your mind imagine life,  objectively?    NEW PIONEERING, COMPREHENSIVE METHODS  FOR SCIENCES AND ALL RESEARCH ARE  ABSOLUTELY URGENT FOR PRACTICING SEARCH FOR MORE  EFFECTIVELY-SOUND KNOWLEDGE. 

    YOUR RESEARCH IS SO TYPICALLY CRUDE, SO HELPLESSLY SICKLY AND SO HOPELESS… YOU MUST START YOUR BASIC EDUCATION WITH studing  about your own tricky perception you so trust that depict on flat screens and graphic tables what you, yourself, think you analyze while these are the results of your mind imagination "interpreting reality" you ultimately manipulate.  READ AND LEARN FROM   Phenomenology of Perception, it is a 1945 fundamental research on human perception by the French philosopher and an outstanding researcher, Maurice Merleau-Ponty. CHEERS.

  2. the epigoni carl jung psychology and alchemy ubiquity s-ame table of content. interesting   e*I pi +1=o square root -1 epiphenomenalism epi  yep gone goni i&e of mathematics 'k-new word [?] gone goni epi~! ubiquity endocrinology endi natural exponential function 'e' Fibonacci  compass and square ontology mereology protothetics system set theory logic .

  3. NEW for geneticists and not only! Here's a novel approach in genetics and a giant step in the genome physiology:
    "The true laws of heredity, Danciu laws of heredity-four new laws".
    These laws invalidate and change almost everything what was written previous about heredity, eliminate all errors of heredity made so far, elucidates exhaustive the mode how the characters are transmitted from parents to descendants, including most autosomal-recessive diseases, are a indispensable tool in medical genetics research of success and in the activity of obtaining of hybrids of plants and animals with high biological value, facilitates the understanding genotype-phenotype relationship and of genetic variation between individuals, at any species, facilitates the identification with more accuracy of recessive genes, namely genes that can not function, though should, causing autosomal-recessive diseases, are valid 100% in all cases and all species that reproduce by gametes.
    The new laws reveals with clarity all the truth regarding heredity, including: the genetics inheritance received of child from each parent is determined of the energy which the gametes, male and female, have at the moment of fecundation; only the sex chromosomes transmitted of father are active in the children's body, X at girls and Y at boys; at any pair of genes, if a gene has a mutation then no the healthy gene can not function; at any valid pair of hereditary factors (chromosomes, genes, nucleotide) can be chosen in the set of active factors only one factor; of all hereditary factors with rank of genes, segments of gene and nucleotide which have the same functional role and are in the set of active factors will be chosen to express only one factor; in meiosis 50%-1 sex chromosome, that is the set of inactive autosome chromosomes, of genome is eliminated, and the remainder of 50%-1 sex chromosome, that is the set of active autosome chromosomes, equips both gamete-brothers; in the human genome is expressed maxim 25% of all genes, because only 50% are admitted in the set of active chromosomes, and of these 1/2 (25% of all) are genes dormant (at animals and plants expressing even much less of 25% of all genes); any process of after fertilization, including the configuration the set of active chromosomes, and starting and stopping of genes expression, is initiated and controlled of the systems of proteins-enzymes (mitochondrias); etc. Details at:
    http://independent.academia.edu/MarinDanciu
    http://www.frontiersin.org/Profile/PublicationDetails.aspx?PubId=39587292&tab=2
    http://scholar.google.co.in/citations?user=OcZRrW0AAAAJ&hl=en

  4. Wasn't me!! I don't think it merited a demerit.

    I know what you mean though. Debates by some groups are just full of people strategically going off topic. People actually get taught how to do that. Lectures are great to watch but its always good to hear what the opposition have to say. But then again, some debates seem to be pre-conceived to arrive at a harmonious climax, which makes me feel quite sick. Academics and the public should stay vigilant and question anything

  5. Although this is off topic, it is fascinating to imagine that something as subtle as a thought process, could somehow trigger changes in the epigenome. Perhaps, therefore that in the future, psychology could PROVE to be a focused preventative/therapeutic treatment for a certain selection of mental, and physical, developmental diseases, through certain 'thought processes'. However, this is just a wild idea, and I am not qualified in this field.

  6. Hi, I found broad casting such lectures very helpful to my as PhD student and lecturer especially that we can attend such meeting or confernces. so thank you. It was a big help to my next seminar on epigenetics. thanks again

  7. Yes, that one is a bit difficult to see. Unfortunately that particular graph is quite hard to read even in the original slide. We'll see whether we can improve the quality in future videos though. Thanks for letting us know.

  8. Hi Lucas, have you tried changing the video quality using the cog icon in the Youtube player? You should be able to increase the quality so that the slides aren't blurred when you enlarge the video. Does that help?

  9. I do like the Society's public lectures, however if you are going to insist on using youtube, could you improve the quality of the slides? Some of the detail is too small and when you enlarge the video the slides show up blurred so you can't read the text – this is frustrating and hasn't been a problem with videos in the past.

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