September 19


"The Role of Methylation and Epigenetics in Brain Disorders" presented by William J. Walsh, PhD

By heheals

September 19, 2020

Did you know that 22% of Americans are undermethylated and another 8% are overmethylated? The emerging science of epigenetics is providing insights into the impact of methylation imbalances on neurotransmission at serotonin, dopamine, norepinephrine, and NMDA receptors, and also provides a roadmap for effective nutrient therapies. William J. Walsh, PhD, presents The Role of Methylation and Epigenetics in Brain Disorders.

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  1. I’m not Schizophrenic, but I feel like I have all the symptoms you have in the over methylating group.

    Over Empathetic , not competitive, extremely depressed my whole life and ssris do not help!
    I have always loved NIacin! First time I took it I had a huge reaction from it which meant I was deficient

    Why are you only giving an example for Schizophrenia?

  2. For anyone that is actively researching their own depression and mental health issues, I started a subreddit for this exact reason. I'm a huge fan of Walsh and many of his findings are on my sub also. If you are actively researching, feel free to check it out. Go to reddit and check out r/researchingdepression. Thanks.

  3. This was an amazing presentation and by far the best I've ever seen regarding the subject of methylation and testing. And to think it has been more than four years since it was first uploaded; that tells me the Walsh Institute was years ahead of the game even back then— and has been attempting to train providers in an effort to help as many people as possible for quite some time now. Thank you 🙏 for your work and I pray your efforts will continue to bless others with many more providers taking your work to-heart (despite the current irresponsible trends in the "modern medical model"— which helps precious few anymore, save for the broken but greedy system itself.

  4. People who have taken the drug accutane are under also under methylated. This is because accutane induces a hypersensitive GNMT enzyme which converts your glycine and SAMe into sarcosine and SAH too quickly. You become deficient then in glycine and SAM and therefore can't methylate properly. It's well known that accutane causes depression and mental problems and this likely has a lot to do with it.

  5. You know, looking at your Under Methylation list — the commonality there emotionally, seems to be connectedness to the outside world … which suggests a tie between dopamine and it's purpose of releasing oxytoxin to the body.

  6. Thanks Dr. Walsh … dietary disorders are a primary issue, unfortunately Modern medicine has abandoned “Root Cause” investigations in favor of “Diagnosis and Drugs” … seems odd as metabolism is a “Response Mechanism” … and we are seeing the results of Medicine by Chemistry, without “Root Cause Analysis” …
    What is scary is trying to balance all of these nutrient requirements … maybe modern sensors will give us solutions … "FitBit" we need real time blood analysis added – ASAP …
    70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit … or if a fan of Ray Kurzweil … then this is all a Moot Point.

  7. If I have bad effects from SSRI's, used to hear voices in psychosis could that be indicative i am an overmethylator? I ordered a bunch of methylfolate before i saw any of the lectures by Dr Walsh should i give it a go?

  8. Our environmental conditions and food supply are becoming increasingly toxic. This information is so important right now.
    Our ability to detoxify this bombardment of toxins, depends on good methylation. Amalgam toxicity, Lyme ,EBV, thyroid and adrenal issues only add to this mess. Everyone needs to hear this! Thank you.

  9. Dear Dr. Walsh, first of all thank you for the great presentation.

    What percent of glutathione made comes from the Homocysteine rather than Dietary Cysteine? Is there any benefit of Homocysteine other than Glutathione production?


  10. Nice presentation,Polymorphisms are just now coming to the forefront with genomics and gene evaluation services like 23andme. Nutrigenetics and Epigenetics are having a positive effect …the individual can become enlightened if one so chooses.70 Going On 100

  11. Very nuanced and holistic lecture of the subject. Fills in many gaps other protocols have including yasko and Lynch's. The folate up regulating sert protein transport and repuptake was particularly crucial insight for me explaining behaviors I'm seeing with our autistic 5 yr old ds.

  12. This is a great talk, but it leaves me asking, what about other reasons for symptoms? For example, vaccines given to young children can cause autism. That link is followed in the movie "Vaxxed." A 2nd example – Lyme disease can cause autism in children born with it or if exposed early on to the bacteria. LIA, ie Lyme-Induced Autism, is an organization dealing with that. I guess this is called a differential diagnosis comment.

  13. The most dangerous methylation agent since more than 100 years is SUGAR which is a mixed substance of many aditives. Industries only foccus 'profit'. They use all kinds of cheap trash ingredients to get the highest profit. God knows what they have been introducing in human diets, human medicines, human water and so forth!!!!!! There is an overload of toxicity in all shelves of industrialized packs, boxes, cans, tetrapack. Just don't buy industrialized foods.

  14. Whilst this seems like interesting research, where are the peer reviewed article links to back this up? Thats bad science, and a major annoyance for people that are looking into this, but need to see the original work done (for university study). Your website mainly consists of powerpoints and papers (scientific journals are few and far between); plus all the work done that is not originally yours?! That is plagiarism.

  15. By year 2005 my colleagues and I had studied the methylation status of more than 25,000 patients with depression, anxiety, ADHD, autism, bipolar, and schizophrenia disorders. We learned that more than two-thirds of these patients exhibited abnormal methylation, and that individualized nutrient therapies yielded high percentages of families reporting great improvement. However, a biochemistry mystery developed that perplexed me for more than 20 years.
    The most common form of depression involves undermethylation, a relative lack of available SAMe methyl donors in the body and brain. Most of these patients exhibit low neurotransmission at serotonin receptors and report benefits from SSRI antidepressants that increase serotonin activity. Biochemists have known for years that the treatment of choice for undermethylation is folate therapy together with B-12. However, after many hundreds of patients it became clear that most undermethylated depressives are intolerant to folate therapy, usually with dramatic worsening in moods.  We learned that this occurred regardless of whether therapy involved folic acid, folinic acid, or n-methylfolate (known as Deplin). I first reported this finding at the 1994 annual APA meeting. For years I searched for a biochemical explanation without success. At one point I erroneously believed the undermethylation impact on tetrahydrobioptrin (BH4) and COMT might be the answer. My consternation continued until the emerging field of epigenetics provided the explanation in 2008. I learned that folates reduce serotonin activity by an epigenetic mechanism. This is the last thing a low-serotonin-activity depressive needs. 
    About 30 years ago brain scientists learned that the amount of serotonin in the brain is of secondary importance in depression, and the dominant factor is reuptake kinetics – the rate at which serotonin in the synapse is returned to the original brain cell (called the presynaptic neuron). Serotonin reuptake depends on the population of SERT transporter proteins that act as passageways for the returning NTs. Gene expression of SERT transporters is powerfully enhanced by all forms of folate. It’s now clear that folates are serotonin reuptake promoters, and SAMe, methionine, and SSRIs are serotonin reuptake inhibitors. The mystery has been solved and I now sleep much better at night.

  16. Nor has this Fellow even once mentioned the critical importance of B12 in nerve function and repair.  His understanding of the methyl cycle is highly limited!  The idea of withholding the active form of folate from those who have mthfr snps (especially those with homozygous snps plus other important snps in the methyl cycle is extremely questionable. 

  17. and I am not at all convinced that all so called depressed undermethylators are intolerant of folates.  Not once did he mention that that may be because they might have a COMT snp or an MAO snp and those snps might need to be supported before even attempting to give methylfolate.  Nor has this fellow mentioned the need to have enough B12 before attempting to give methyl folate either due to the fact that not doing so will create a methyl trap.
    The only time he mentioned such snps was in the context of those with methyltranferase snps are considered over methylators….Then he moved on to the transporter receptor issue.
    I am not impressed at this point.

  18. I am sorry, but this guy need to take some courses on methylation from Dr. Ben Lynch! He is making conclusions that normal parts of the methyl cycle are somehow harmful or aberrant.  5-mthf is suppose to lose its methyl group in the process of donating it to homocysteine (not histamine as he mistakenly states) to be turned back into thf as thf is used to create other forms of folate that are necessary in other pathways.  This is not harmful or aberrant or a problem.  And this is just one example of problems I am having with this guy's understanding of methylation issues.  Everything is a balance in the body.

  19. Being a mother of a 10 year old boy using Dr. Walsh's approach to undermethylation with an ODD diagnosis, I can say that the process has been quite amazing. We aren't seeing overnight success, but slow changes in his impulse control are there. We are looking forward to continuing watch of the effects…This presentation is great and I have shared with several parents and professionals working with children with behavioral disorders. THANK YOU

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