Dr. Shinya Yamanaka discovered a group of proteins that can reprogram differentiated (mature) cells into pluripotent stem cells. These proteins, now called Yamanaka factors, are highly expressed in embryonic stem cells in mice and humans. Their short-term expression can ameliorate cellular and physiological hallmarks of aging and prolong lifespan by resetting the Horvath epigenomic clock. In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenomic clock.
This clip was taken from the FoundMyFitness interview with Dr. David Sinclair found at https://youtu.be/5DtWqzalEnc
Original episode published on Nov 6, 2019