September 25

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The Hallmarks of Aging: Epigenetic Alterations | LifeXtenShow

By heheals

September 25, 2020




Did you know that your genes can be switched on and off? They can, and while this is mostly okay, it’s also one of the reasons we age—and we just might be able to do something about it.

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Music:

Intro jingle courtesy of Kevin MacLeod – Incompetech.com

“Hungarian Rhapsody N. 2”, by Franz Liszt, licensed under cc-by-sa Germany license by Bernd Krueger, http://www.piano-midi.de

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Sources & further reading:

The hallmarks of aging:
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/)

Influence of smoking on epigenetics:
Lee, K. W., & Pausova, Z. (2013). Cigarette smoking and DNA methylation. Frontiers in genetics, 4, 132. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713237/)

Talikka, M., Sierro, N., Ivanov, N. V., Chaudhary, N., Peck, M. J., Hoeng, J., … & Peitsch, M. C. (2012). Genomic impact of cigarette smoke, with application to three smoking-related diseases. Critical reviews in toxicology, 42(10), 877-889. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491444/)

Knopik, V. S., Maccani, M. A., Francazio, S., & McGeary, J. E. (2012). The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Development and psychopathology, 24(4), 1377-1390. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581096/)

Influence of chronic stress on epigenetics:
Hunter, R. G. (2012). Epigenetic effects of stress and corticosteroids in the brain. Frontiers in cellular neuroscience, 6, 18. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329877/)

Cunliffe, V. T. (2016). The epigenetic impacts of social stress: how does social adversity become biologically embedded?. Epigenomics, 8(12), 1653-1669. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289034/)

Rusconi, F., & Battaglioli, E. (2018). Acute stress-induced epigenetic modulations and their potential protective role toward depression. Frontiers in molecular neuroscience, 11, 184. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990609/)

Chromatin remodeling and transcriptional alterations in progeroid syndromes:
Oberdoerffer, P., & Sinclair, D. A. (2007). The role of nuclear architecture in genomic instability and ageing. Nature reviews Molecular cell biology, 8(9), 692. (https://www.nature.com/articles/nrm2238)

Epigenetic changes in aging:
Kane, A. E., & Sinclair, D. A. (2019). Epigenetic changes during aging and their reprogramming potential. Critical reviews in biochemistry and molecular biology, 54(1), 61-83. (https://www.tandfonline.com/doi/abs/10.1080/10409238.2019.1570075)

Euchromatin and heterochromatin in progeroid syndromes and aging:
Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., … & Yuan, T. (2015). A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science, 348(6239), 1160-1163. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494668/)

Scaffidi, P., & Misteli, T. (2006). Lamin A-dependent nuclear defects in human aging. Science, 312(5776), 1059-1063. (https://www.ncbi.nlm.nih.gov/pubmed/16645051)

Partial cellular reprogramming with OSKM:
Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., … & Araoka, T. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell, 167(7), 1719-1733. (https://www.cell.com/fulltext/S0092-8674(16)31664-6)

Alternative partial cellular reprogramming approach by Turn.Bio:
Sarkar, T. J., Quarta, M., Mukherjee, S., Colville, A., Paine, P., Doan, L., … & Rando, T. A. (2019). Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells. bioRxiv, 573386. (https://www.biorxiv.org/content/10.1101/573386v1.full)

https://www.leafscience.org/an-interview-with-prof-vittorio-sebastiano-of-turn-bio/ https://www.leafscience.org/partial-cellular-reprogramming-to-reverse-cellular-aging/
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#Aging #Epigenetics #Biology #Science #Rejuvenation #LifeExtension

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heheals

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  1. Very informative! We're only just starting to see the effects of Yamanaka factors playing out in the real world, and I'm very excited to see where that breakthrough will take us next. Great video, thank you!

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