September 26


Can You Age Backwards? Dr. David Sinclair Explains Epigenetic Reprogramming & Life Extension · #135

By heheals

September 26, 2020

Is there no limit to human longevity?

The latest, most cutting-edge research in aging paints a fascinating picture for our future.

Much of this work comes from the mind of Dr. David Sinclair, a Professor in the Department of Genetics at Harvard Medical School & the author of New York Times Bestseller “Lifespan: Why We Age – And Why We Don’t Have To”.

Dr. Sinclair’s leading hypothesis for why we age and how we can manipulate our biological clock is dubbed the “Information Theory of Aging”. Essentially, he believes each cell has an original DNA copy that can be activated and restored to a youthful state.

One’s chronological age may be an undisputed 50 years old, but through Dr. Sinclair’s theory could that person reverse their biological age and match the health markers of someone who is 25 years old?

He joins the H.V.M.N. Podcast to expand on the biological mechanisms behind his theory, the discoveries from his research, and what we can potentially do today to extend our lifespan.

Topics Discussed:
· Epigenetic reprogramming
· What the “Observer” could be and alternate explanations for its mechanism
· Hormesis
· Horvath’s clock
· Metabolic and cellular pathways for longevity
· Potential interventions for longevity: Nutrition, cold exposure, metformin, resveratrol, NAD+, ketones

Dr. David Sinclair’s book:
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Disclaimer: Dr. David Sinclair is not affiliated, associated, authorized, endorsed by, or in any way officially connected with H.V.M.N.



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  1. This is a great interview. Very different from other interviews Dr. Sinclair had given on other media outlets. Awesome! I love his work and his personality. Thank you for sharing this with the world!

  2. This guy can't even keep an Apple from rotting or a Mouse from dieing and the human organism is the most complicated piece of life that has ever been on this planet so do the math y'all. Like all the rest just another educated fool whether he knows it or not and how pathetic.

  3. Yeah Im Dr Sinclairs age and we definitely don’t want to be the last generation to get old and die off. I’ll continue to adopt his evolving protocols as the years pass until we get to the finish line. The next 10-15 years will be interesting for this field. Stay healthy and save your money.

  4. Why is the interviewer arguing with this expert, shut up!!! and the interviewer runs his words together he can’t talk clear and he stutters!! Learn the basics like how to speak clearly before you move on to arguing with an expert!!!!🙄🙄🙄🙄🙄🙄🙄🙄🙄🙄🙄🙄🙄

  5. David Sinclair feels that a whole food plant based diet is the healthiest and is what he follows. Exception is eating some meat on days he exercises which, he states, is one day on the weekend with his son.

  6. The Professor David Sinclair is so brilliant. Every interview he gives is so interesting , excellent and teaches something new. I’m so grateful to live at his age, to be able to improve my lifespan with the knowledge that he so kindly, like no one else did, reveals to the world. Lifespan book is a real treasure I cannot emphasize enough how much it helped me and helps those who aim to take control of their health and lifespan.

  7. Regarding the 19m/27m mark on the observer, in the elife podcast(#62) they mention how tardigrades can live in the most extreme environments and are not affected by high radiation due to a damage suppressor protein that covers chromatin, protecting its dna from hydroxyl radicals. It's unclear how this shield is then removed in order for normal methylation / gene expression, but I wonder if this is something David has looked into?

  8. what an awesome interview and really it just gives me ASMR all over listening. David Sinclair good on ya for sharing your research in such simple terms for the world; it takes a special person to do that without any hopes of profit the only gain remains knowledge and i do agree we need to be able to live better human lives.

  9. Therefore, technically with this approach that Dr. Sinclair suggests, our "aged" cells be it that they are as old as we are chronologically, the original DNA is extremely well preserved, and can probably last centuries or longer, in some sense inert. Hence "aging" is really redefined by a change or shift in paradigm from DNA damage, to more or less the epigenetic level by methylation of our genes, and similar processes. Thus the switches that turn off excellent parts of our genes, or turn the bad parts of our genes on, are the culprit, and hopefully this change to extend or refresh the cells will not disrupt or unbalance another system in our bodies. Hence there is no requirement for new stem cells per tissue type to replace existing damaged cells, because the cells can be refreshed and rebuilt by the genomes via refreshing the Epigenetic sets.

  10. Each cell must have the master framework for recovery to an extent (as long as genomic data is not lost or damaged over time including the lineage via mitosis overtime per tissue type. Probably the original framework is tertiary in nature, equivalent to an "epi-epigenome" that could even be temporal in nature and involve 3D structural motifs of nucleosomes and DNA. Anyhow we need to apply advanced creativity to solve this issue, and have an open mind. The master framework or instruction set must be packaged in the cell somehow, we need to greatly expand our net to capture these events during the transformations, and catch it during the minutes, and hours that a cell goes back to baby mode (stem cell mode).

  11. It's too bad that Dr. Sinclair didn't answer, and in fact didn't appear to even understand, the reviewers "challenge" (which posed an alternate explanation for an "observer" that can reset the biological clock). The way to test for whether a cell that gets "reset" back to the stem cell stage isn't just "mimicking" the most healthy cells around it wouldn't be demonstrating age reversal a specific type of cell in the petrie dish (as Dr. Sinclair seemed to be saying). The actual evidence (refuting the "challenge") would be to reverse the aging process in a single ISOLATED cell in the petrie dish. I don't know if Dr. Sinclair truly didn't understand the question (which seemed fairly obvious to me) or whether he was being deliberately evasive (because the "challenge" was a plausible explanation he hadn't thought of).

  12. In poland we recently had a bit of scandal meaning in germany which is our neighbour they found that in metformin drugs there were rat poison contamination. Idk where metformin in US or Australia is manufactured but it is possible that like ours its in china. So maybe it is a good idea to check yours. Im not an expert or anything I dont take metformin but i say what i heard and im jus sayin.

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