Epigenetic changes are an epi-phenomenon that happens on—not in—the genetic code of an individual. These marks regulate cellular and physiological phenotypic trait variations caused by external or environmental factors, which switches genes on and off without changes in the DNA sequence throughout evolution. Epigenetic changes may not only serve as a memory timestamp for the day-to-day lifestyle of an individual, but are also an evolutionary timestamp and have contributed to who we are as a species.
Malav Trivedi, Ph.D., is an assistant professor at NSU’s College of Pharmacy. He has authored several manuscripts implicating the role of metabolic changes and epigenetic-based gene expression changes in neurodevelopmental and neuropsychiatric disorders. His continuing preclinical and clinical research indicates that opioids and food-derived opioid peptides induce oxidative stress and epigenetic changes. This can affect inflammatory status and potentially contribute to gastrointestinal and neurological manifestations. Trivedi’s work includes the fields of molecular biology, nutritional biochemistry, pharmacology, and neuroscience. His research interests also include mitochondrionomics, epigenetic and transcriptional changes in
neurodevelopmental disorders (e.g., Autism), drug addiction and withdrawal, neurodegenerative diseases (i.e., Alzheimer’s and Parkinson’s), and tumor biology and the microenvironment.
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