September 26


Genetic strategies for reversing epigenetic age (Horvath Clock) | David Sinclair

By heheals

September 26, 2020

The Horvath clock, a means of assessing a person’s “epigenetic age,” measures DNA methylation levels, which increase as a person ages, and can even predict how long a person will live. Recent discoveries in the field of aging research may have identified the signal that can manipulate the epigenome to restore proteins – including sirtuins – to their earlier, younger functional capacity. In this clip, Dr. David Sinclair describes how epigenomic modifications can influence how an organism ages, potentially reversing years of age-related damage.

This clip was taken from the FoundMyFitness interview with Dr. David Sinclair found at

Original episode published on Nov 6, 2019



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  1. Interesting. I was one of those people who burned that candle at both ends, so to speak. I was overweight for most of my life, and a beer drinking savage. Thankfully I've lifted weights most of my life, so that taught me discipline.

    I discovered Dr. Patrick via Joe Rogan's Podcast and those talks she had with Joe really gave me the information I needed to try to turn my life around. I've went from 230 lbs down to 165 lbs and I feel alive again. Been sober for 16 months, and I've been eating as healthy as humanly possible, I run twice a week, still lift weights, etc… I'll be 42 next week, and I feel better than I did when I was 32, and even 22!

    The irreversible damage I've done cannot be undone, but I learned from it. Thank you Dr. Patrick and Dr. Sinclair for giving us laymen types some direction for our health.

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