September 27


Structural biology of gene, epigenetic and immune regulation

By heheals

September 27, 2020

Structural biology of gene, epigenetic and immune regulation

Air date: Wednesday, June 21, 2017, 3:00:00 PM

Category: WALS – Wednesday Afternoon Lectures

Runtime: 01:11:08

Description: NIH Director’s Wednesday Afternoon Lecture Series

The role of RNA in information transfer and catalysis highlights its dual functionalities. Much of Dr. Patel’s laboratory effort in this area has focused on metabolite-sensing riboswitches and nucleolytic self-cleaving ribozymes on the one hand, and on CRISPR-Cas systems on the other. His WALS lecture will provide a few examples of the principles underlying metabolite recognition by riboswitches; his lab’s studies on catalytic mechanisms adopted by nucleolytic ribozymes; recent x-ray and cryoEM studies on ternary complexes of Cas nucleases and multisubunit cascades with bound crRNA and target DNA; and the impact of anti-CRISPR proteins in suppressing the CRISPR-Cas host-defense pathway.

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Author: Dinshaw J. Patel, Ph.D., Member and Laboratory Head, Memorial Sloan-Kettering Cancer Center

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