September 29


Epigenetics – no narration

By heheals

September 29, 2020

X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying epigenetics. Epigenetics refers to processes that tell our cells how, and when, to read the DNA blueprint. The epigenetic regulation of DNA is critical in both normal development and disease.

X inactivation is a type of gene dosage compensation.

In humans, the sex chromosomes X and Y determine the sex of an individual – females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development.

Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down’s syndrome, which is caused by an extra copy of part or all of chromosome 21.

In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell ‘switches off’ one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.



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  1. I love the background noises. Obviously the sounds are made up, but they fit so well! Can I request a video on how the methyl binding proteins work? A visual representation of how they recruit other transcription factors, bind them and alter the chromatin structure, silencing a gene. Even better could be a comparison with an aberrant case such as in Rett Syndrome where MeCP2 is faulty and a visual representation of what goes wrong at the intra-cellular level?

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