Air date: Wednesday, October 27, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Lecture Summary:
Expression profiling of eukaryotic genomes has revealed widespread transcription outside the confines of protein-coding genes, leading to the production of antisense and non-coding RNAs. Studies in Schizosaccharomyces pombe and multicellular organisms suggest that transcription and non-coding RNAs provide a framework for the assembly of heterochromatin structures, which have been linked to various chromosomal processes. In addition to gene regulation, heterochromatin is critical for centromere function, cell fate determination as well as transcriptional and posttranscriptional silencing of repetitive DNA elements that are known to be major source of genomic instability. We have found that heterochromatin factors are widely distributed across euchromatic loci and collaborate with RNAi machinery to suppress antisense transcripts across large portions of the genome. Our recent progress in understanding the mechanisms of heterochromatin assembly, and the roles of RNAi and heterochromatin factors in epigenetic genome control will be discussed.
1. Discuss roles of RNAi machinery and non-coding RNAs in heterochromatin assembly.
2. Roles of heterochromatin machinery in gene silencing and maintenance of genome stability.
3. Novel genome surveillance mechanisms essential for silencing retrotransposons.
The NIH Director’s Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Shiv Grewal, Center for Cancer Research, National Cancer Institute
Permanent link: http://videocast.nih.gov/launch.asp?16229