Every cell in the human body contains the same DNA and are different due to Epigenetics. Epigenetics means “on top of “or “above” genetics and refers to external modifications or marks on DNA or DNA bound proteins that act as light switches to turn genes “ON” or “OFF”. What genes that are turned “ON” or “OFF” defines for example a muscle cell from a nerve cell. Our cells are constantly exposed to damages that can cause genetic lesions and epigenetic aberrations. Faulty epigenetic switches can alter expression of genes and can cause rewiring of the entire cell identity. This may have major impact on the cell and is often what we see in cancer development and progression.
Learn more about Cancer Epigenetics in the Chromatin Biology group at Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, The Medical Faculty, University of Oslo, Norway.