October 11

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The Epigenetic Basis of Common Human Disease

By heheals

October 11, 2020




The Epigenetic Basis of Common Human Disease

Air date: Wednesday, September 03, 2014, 3:00:00 PM

Category: WALS – Wednesday Afternoon Lectures

Runtime: 00:59:42

Description: Wednesday Afternoon Lecture Series

Although epigenetic changes in the cancer genome have been known for three decades, the role of epigenetics in common human disease and its relationship to genetic variation has only recently begun to be explored. The Feinberg lab has been developing whole-genome approaches to the epigenetic analysis of human disease and contributing to a new field of epigenetic epidemiology that integrates genetic, epigenetic, and environmental factors. One of the most exciting developments in this recent work is the idea that epigenetic plasticity under genetic control may confer a survival advantage in evolution, and may also be important in normal tissue differentiation and response to the environment. Dr. Feinberg has suggested a unifying model of cancer in which epigenetic dysregulation allows rapid selection for tumor cell survival at the expense of the host.

For more information go to http://wals.od.nih.gov

Author: Andrew P. Feinberg, M.P.H., M.D., Gilman Scholar and Professor of Medicine Director, Center for Epigenetics, Johns Hopkins University School of Medicine

Permanent link: http://videocast.nih.gov/launch.asp?18582

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  1. 25:06 full slide, 'Stochastic Epigenetic Variation as a Driving Force of Evolutionary Adaptation'
    – for the evolution of complex species (multicellular)
    – stochastic variation plays a fundamental role during normal development
    – this stochastic variation is mediated epigenetically
    – the degree of stochastic variation is inherited genetically
    – genetic variants that increase epigenetic plasticity couldincrease fitness over evolution, for traits affected by a fluctuating environment
    reference: Feinberg, Irizzary, PNAS (2010) http://www.ncbi.nlm.nih.gov/pubmed/20080672

    38:14 Hypervariable methylation predicts cancer risk
    reference: Teschendorff et al. (2012) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446274/

    39:06 Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
    reference: Timp & Feinberg, Nature Reviews Cancer (2013) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636434/

    40:10 Epigenome wide association studies and GWAS re: rheumatoid arthritis

    49:20 mention of LSD1 inhibitors (lysine specific demethylase) as potential therapeutic agents

    49:50 full slide, summary of lecture

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