October 12


Endocrine Disruptors and Epigenetics and Heritable ADHD

By heheals

October 12, 2020

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A new study on endocrine disruptors, pregnancy, and heritable ADHD and other neurodevelopmental issues. Women exposed to endocrine disruptors seem to be able to pass ADHD and other disorders onto their grandchildren! That is unusual.

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  1. 1:19
    Why does it say "December 27, 2016" when the article is published in May 2018?
    It even cites a conference from 2018 as a source

    Btw, I did not find it in the article, but did they control their findings with the sex of second generation (F1) parents (children of mothers who took EDC)? From what I can make out of the article, they only used female F1 participants.

    If the increased risk is only if your mother's mother took the EDC during pregnancy, it could be that the effects were not inherited.
    Perhaps the EDC influenced the further development of the fetus, resulting in abnormalities in the reproductive system of women, making them more likely to have children with ADHD.
    If it is truly epigenetics, the increase should also be seen if F1 is male.
    Wild speculation of course (not an expert), but as the authors did not state that F1 participants are all female were a limitation, I don't think the researchers have considered such an option.

    To be fair, they probably have a grounded reason to dismiss my speculation right away. The researchers know more than me on this subject.

  2. 0:23 – I strongly feel your comments regarding ADHD are incredibly reductive and really miss the mark. As a person with ADHD myself, I’ve managed it with the help of medications and most importantly, therapy, including individual and group therapy (support groups), not to mention books and the wonderful inventions of modern technology that help me successfully manage my life so that I AM a successful adult with a great quality of life. My point is, while the struggles that you say affect us ADHDers, I’m saying they don’t HAVE to be as there there is enough support through medication, therapy, and even literature about HOW to manage ADHD to help.

  3. Was this drug prescribed world-wide, and how does this study control for that? For example, are the rates of ADHD the same among societies that used it and those that didn't? And could it merely have exacerbated the already existing neurological variation, perhaps making it more symptomatic in later generations?

  4. On epigenetics, it is worth noting that there is very little evidence for transgenetational inheritance in mammals. In plants, my system, we know a lot more. In mammals, DNA methylation gets wiped twice between generations. There are other possible mechanisms or ways for DNA methylation to escape this, but this is speculation. It would be extremely exciting to find examples of transgenerational inheritance in mammals, but currently we only have circumstantial evidence.

    In my mind, the most plausible explanation is changes in behaviour bought on by exposure to the grandmother or the (then in utero) parent could alter behaviour. This change on behaviour lead to the changes in the risk of grandchildren developing ADHD.

    If you ever want to reach out to me to discuss topics of epigenetics further, please feel free. I am currently a researcher at the University of Western Australia. I fear is that the term epigenetics is very ill-defined (some definitions focus on transgenerational inheritance like you did, others use it to describe any change in gene expression). I find that this term is being used more and more to manipulate the public and the general understanding of genetics. So an improved understanding of this would help the public a lot.

  5. My mom took DES, but only with my older brother, not with any of her daughters. One of her nine grandchildren has been diagnosed with ADHD. My brother does not have any children. Thankfully, my mother was born in 1937, just before the drug came out. I know of three or four women of my age whose mothers took DES and who have been diagnosed with uterine cancers way earlier than expected. One was 17, two others were in their late 30s or early 40s. At least two have died.

  6. Great video but what you didn't touch on was because the drug was taken during pregnancy there was a direct exposure to the 2nd generation meaning that if it caused a physical defect in the 2nd that could explain the adhd in the 3rd generation so the study needed to expand to 4th generation to prove epigenetic mechanisms over physical defects.

  7. Hi Healthcare Triage, what are your thoughts on intermittent fasting (e.g. 16-8 fasting, 24-hour fasts, 36-hour fasts)? I wanna know what the research tells us about fasting. Is it good? Is it bad? Are there harmful side effects? Are there long-term negative effects on overall health?

  8. One problem with this is that a lot of neuroatypical people, including myself, don't even agree with neurodivergences like ADHD and ASD being classified/seen as inherently bad, but rather as natural diversity on a neorological level; we see it as that our social, educational, etc. environments are by and for neurotypical people and are therefore difficult for us, i.e. it's an external, structural problem rather than an internal, neurological problem, and we don't believe in "curing" ADHD or ASD the same way that mutants in X-Men don't believe in a cure. This is not to say that we shouldn't understand and limit environmental factors causing increases in frequency/severity, but that research into things like genetic and epigenetic factors could lead to a "cure" that could be administered to children before they are old enough to understand and consent, or even to parents before they have kids, preventing any new ADHD or ASD adults, which would be terrible. You can ask neurodivergent people and nearly every single one of us will tell you that as hard as it can be making this world work for us, we would never willingly "cure" ourselves.

  9. I'm glad that the only thing anyone seems to have gotten out of this is that there's a typo in the thumbnail. Meanwhile I googled what that med was originally given for and what the heck an endocrine disruptor is.

  10. Aah. Des still havng effect, who would have thought?
    Or more accurately: how could we have thought any different after the initial dangers became clear?

    I still don't think my grandmothers used it, my parents would've known. Yet I have autism and ADHD.
    It just runs on my father's side of the family, mostly the male side.

  11. Although the word data is the same whether it's singular or plural, it's always treated as a singular in a sentence. Every time you say 'the data were' in this video it should be 'the data was.' At 2:28 for example.

  12. Hum really interesting. I wonder if this would explain some of the increase in diagnoses of ADHD over the last few generations.
    It would be interesting to check levels against countries that did not use this drug, and ones where it is still prescribed (if any).

  13. This is really special, interesting information! I was diagnosed with ADHD as an adult last year, and my mom is really surprised by my diagnosis. It's probable my dad had ADHD to some extent, but I'm not sure. My grandmother isn't around to ask about this drug, unfortunately. However, my ADHD situation also reflects well known comorbidity with Restless Leg Syndrome and female obesity, so there's clearly more going on here than just my ADHD.

    Thanks for sharing this info!

  14. Is there anyway to get my Grandmother or Great-Grandmothers' medical records? Are they still only able to be gotten by them? What if they are dead? Who has claim to the records?

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