October 12

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EPIGENETICS & CHROMATIN STATES – An introduction to histone modifications & gene transcription roles

By heheals

October 12, 2020




This lecture introduces you to histones and histone modifications and how they contribute to transcriptional regulation. It is an ideal starting point for those who are new to the subject or professionals in other fields needing a quick primer.

Contents:
0:35 Defining the epigenetic memory of gene expression
2:37 Chromatin and histones
7:12 Histone modifications
7:59 Histone acetylation and reading by bromodomain proteins
12:02 Histone methylation and reading by chromodomain proteins
19:17 The complex language of histone modifications
21:53 How a core set of marks help define chromatin states

This lecture is brought to you by Dr Adam West in the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. We hope you found this video useful. Please support us by liking the video and consider subscribing for more informative content. Leave us a comment if you thought this video was helpful or if there is further information you would like to share with us and the community. Thank you!
https://www.gla.ac.uk/people/adamwest

https://www.facebook.com/GenomicsGurus

Download the Epigenetic Modifications poster from Abcam here: https://www.abcam.com/pathways/epigenetic-modifications-poster

Read more about ChromHMM and view the data here: https://www.encodeproject.org/search/?searchTerm=chromhmm

Use my UCSC genome browser session to look at chromatin states in your cells of interest:
https://bit.ly/HOXBUCSCGenomeBrowser

CC licensed content, shared previously:
Chromatin fibre model: Marx V. Epigenetics: Reading the second genomic code. Nature. 2012 491(7422):143-7. doi: 10.1038/491143a.

Homeotic gene diagram: Biology. Provided by: OpenStax CNX. Located at: http://cnx.org/contents/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8. License: CC BY: Attribution. License Terms: Download for free at http://cnx.org/contents/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8

Animated nucleosome structure model: https://proteopedia.org/wiki/index.php/1aoi

Chromatin condensation and histone folding diagrams: Johnson A.D., Alberts B., Morgan D., Lewis J., Roberts K., Raff M. and Walter P. Molecular Biology of the Cell, Sixth Edition. WW Norton. ISBN: 978-1-317-56374-7

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