October 13


AHS17 Diet and Gene Expression: the Epigenetics of Low-carb and Low-fat Diets – Lucia Aronica

By heheals

October 13, 2020

We tend to think that good genes make us thin and healthy, whereas bad genes make us fat and sick. But what if we could turn our “good” genes on and our “bad” genes off by making right lifestyle choices? The science of epigenetics suggests this is true. Lifestyle factors, diet in particular, can modify molecular switches on our DNA, which can turn genes on or off. These switches are known as epigenetic marks. My research investigates whether different diets (i.e. low-carb vs. los fat) can induce different epigenetic changes, and whether these changes contribute to make us gain or lose weight diet. By comparing diet-induced epigenetic changes between the high and low responders to either a low-carb or a low-fat diet, we aim to identify epigenetic biomarkers of weight loss or regain for personalized weight-loss strategies.



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  1. I tried both strategies for very long, very precise logging of foods on diary. I do sport daily, never binge eat, that kind of person. Also I like all true foods, not junk foods, a soup is tastier than a cake to me. It ends I tolerate at best starches as potatoes and many grains and lean meats, expecially organ meats. Not so much fruits and fats. Not great tolerance for too much fibre thou, limited for legumes. Same calories, same protein, low fat makes me leaner and gives no lethargy after meals. Starches let me satiated for hours. Fats make me bloated and sluggish and not fully satiated. Still I have some fat rich meal during the month. And going as wide as possible on the diversity of food's sources. And I eat in a time restricted window, which improves the insuline sensitivity a lot.

  2. For unrefined vegans taking vitamin b12 who want to get most calories from fatty unrefined foods, can eat soy, coconuts, nuts, seeds, avocado, durian, whole cacao beans or cacao nibs, etc. There are indigenous diets and traditional diets that had plenty of soy, coconuts, nuts, seeds, etc.

  3. Most of us are descended from agricultural groups that have genetic adaptations to eat cheap staple foods like whole grains, potato, sweet potato, etc. Inuit have unique genetic adaptations to eat plenty of fatty animals. About half of people have genetic adaptations to consume dairy that helped survival in the past. The healthy diets found in blue zones like the 1949 okinawa diet is probably healthy for everyone whatever special genetic adaptations you may have. Dairy has 0 fiber so it is not an optimal food and most people should do ok without dairy even if some have genetic adaptations to consume dairy. Harvard Healthy Eating Plate says to limit dairy bec dairy is linked to cancers like prostate cancer.

  4. Super interesting,The indication of transgenerational transfer of epigenetic gene expression is really interesting and may be very important for people to know if major differences in lifestyle management for better outcomes still prove elusive for some,now I know why I have had to work so hard just to have health parity!My Mum was a serial yoyo dieter and carb addict and I appear to have been disadvantaged possibly due to her choices,I appear to be super sensitive to any bad choices!

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